Behind the Scenes at HistoSpring – Meet the Team and Technology Driving Research Forward

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In the rapidly evolving field of biomedical research, access to advanced histological services and cutting-edge technology is paramount. HistoSpring stands at the forefront, offering specialized histology solutions that empower researchers to delve deeper into tissue-based studies with precision and efficiency.

What is HistoSpring and What Makes It Unique?
Researchers aiming to advance tissue-based studies often seek specialized histology laboratories equipped with advanced technologies and expert services. Collaborating with HistoSpring provides access to high-end equipment and specialized support typically beyond the scope of individual labs, ensuring that complex histological analyses are executed with quality and precision.

Who Are the Experts Behind the Work?

  • Dr. Sallie Schneider: As an expert in immunohistochemistry (IHC), hematoxylin and eosin (H&E) staining, and cell culture, Sallie has been instrumental in guiding client projects from conception to completion in the Histology process. Additionally, her in-depth knowledge has led to the authorship of over 70+ manuscripts on breast cancer research, contributing to advancements in early detection methods and the development of more effective therapies.
  • Dr. Kelly Gregory: An expert in laser capture microdissection, RNA/DNA isolation, and HALO digital image analysis, Dr. Gregory’s proficiency ensures that tissue samples undergo a precise preparation process and actionable recommendations.

What Services Does HistoSpring Provide?
HistoSpring offers a comprehensive suite of services tailored to meet the diverse needs of biomedical researchers:

  • Tissue Embedding, Sectioning, and Precision Slide Preparation: Ensuring high-quality samples for analysis.
  • Immunostaining and Specialty Stains: Providing detailed visualization of specific cellular components.
  • Antibody Optimization and Biomarker Analysis: Facilitating the identification and validation of critical biomarkers.

What Advanced Equipment Powers the Lab?
At HistoSpring, our commitment to excellence is reflected in our investment in state-of-the-art histology equipment. These advanced instruments not only enhance the precision and efficiency of our processes but also provide researchers with capabilities that are often beyond the reach of standard laboratory setups. Here’s an overview of the key equipment that empowers our lab:

Leica Bond RXm Robotic Immunostainer

This automated system streamlines immunohistochemistry (IHC) and in situ hybridization (ISH) staining processes. Capable of handling up to 48 slides simultaneously, it ensures consistent and high-quality staining results, reducing manual intervention and variability.

Leica ASP300S Tissue Processor

Designed for efficiency, this processor can handle up to 300 tissue cassettes in a single run. Its high-throughput capability accelerates sample preparation, minimizes handling errors, and maintains tissue integrity throughout the processing cycle.

Laser Capture Microdissection (LCM)

Our LCM technology allows for the precise isolation of specific cells or regions from tissue sections. This contact-free method ensures uncontaminated specimen collection, facilitating downstream molecular analyses such as RNA/DNA extraction and protein studies.

Aperio CS2 Slide Scanner

The Aperio CS2 converts traditional glass slides into high-resolution digital images. With 20x and 40x magnification capabilities and a five-slide capacity, it enables detailed examination of tissue morphology and biomarker distribution. The scanner’s rapid imaging and intuitive interface supports digital navigation, zooming, streamline analysis and remote collaboration.

How Does this Equipment Benefit Research?
HistoSpring’s advanced histology equipment empowers researchers to conduct complex tissue analyses with greater accuracy and efficiency. Here are some benefits you can reap:

  • Accessing Specialized Tools: Researchers gain access to sophisticated instruments that may not be available in their own laboratories.
  • Enhancing Efficiency: Automated processes save time and reduce variability, leading to more reliable results.
  • Improving Data Quality: High-resolution imaging and precise sample preparation enhance the clarity and accuracy of data.
  • Facilitating Collaboration: Digital slide scanning and remote access capabilities support seamless collaboration among research teams.

What’s It Like Working with HistoSpring?
At HistoSpring, collaboration is at the heart of our approach. Our team, led by Dr. Sallie Schneider and Dr. Kelly Gregory, works closely with researchers to understand the unique aspects of each project. By combining their extensive expertise in histology and microscopy, they provide tailored solutions that address specific research challenges. This personalized guidance ensures that each study benefits from meticulous attention to detail and a commitment to advancing scientific discovery.

Why Choose HistoSpring as Your Histology Partner?
Choosing HistoSpring means partnering with a team that integrates seamlessly into your research process, offering both technical excellence and personalized support.

As one of our Biotech Partners Stated, “Our team partnered with HistoSpring for histological analysis, and their expertise was invaluable. They guided us through sample preparation, collection, and analysis with professionalism and provided exceptional support to meet a critical milestone on a tight timeline.”

Let’s collaborate together. Contact us at 413-794-0523 / info@histospring.com.

 

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